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etravirine will minimize the extent or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.apalutamide will lessen the level or influence of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with medication